Epidemiology of Overdose Deaths

Development and Validation of Machine Models to Classify Substances Involved in OverdoseThis diagnostic study assesses the use of natural language processing and machine learning to identify substances related to overdose deaths in medical examiner data.

Emerging characteristics of isotonitazene-involved overdose deaths: a case-control studyCase reports of fatal overdoses involving the novel synthetic opioid isotonitazene have prompted the U.S. Drug Enforcement Administration to consider an emergency scheduling of the drug in June 2020. We aimed to epidemiologically characterize deaths involving ...

Xylazine spreads across the US: A growing component of the increasingly synthetic and polysubstance overdose crisis - PubMedXylazine is increasingly present in overdose deaths, linked to the proliferation of illicitly-manufactured-fentanyls. Ethnographic accounts associate it with profound risks for PWID. Nevertheless, many jurisdictions do not routinely test for xylazine, and it is not comprehensively tracked nationally …

Responding to the opioid crisis in North America and beyond: recommendations of the Stanford–Lancet CommissionThe Stanford–Lancet Commission on the North American Opioid Crisis was formed in response to soaring opioid-related morbidity and mortality in the USA and Canada over the past 25 years. The Commission is supported by Stanford University and brings together diverse Stanford scholars and other leading experts across the USA and Canada, with the goals of understanding the opioid crisis, proposing solutions to the crisis domestically, and attempting to stop its spread internationally. Unlike some other Lancet Commissions, this one focuses on a long-entrenched problem that has already been well characterised, including in several reviews by the National Academies of Sciences, Engineering, and Medicine.

Steep increases in fentanyl-related mortality west of the Mississippi River: Recent evidence from county and state surveillanceOverdose deaths from synthetic opioids (e.g., fentanyl) increased 10-fold in the United States from 2013 to 2018, despite such opioids being rare in i…

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